Pseudallenes A and B, new sulfur-containing ovalicin sesquiterpenoid derivatives with antimicrobial activity from the deep-sea cold seep sediment-derived fungus Pseudallescheria boydii CS-793

• Zhen Ying,
• Xiao-Ming Li,
• Sui-Qun Yang,
• Hong-Lei Li,
• Xin Li,
• Bin-Gui Wang and
• Ling-Hong Meng

Beilstein J. Org. Chem. 2024, 20, 470–478, doi:10.3762/bjoc.20.42

• compound 1, crystals suitable for X-ray crystal analysis were obtained by slow evaporation of the solvent, which could be analyzed by X-ray diffraction analysis using Cu Kα radiation (Figure 4). The resulting Flack parameter, 0.019(6), allowed the assignment of the absolute configurations of all the

Application of N-heterocyclic carbene–Cu(I) complexes as catalysts in organic synthesis: a review

• Nosheen Beig,
• Varsha Goyal and
• Raj K. Bansal

Beilstein J. Org. Chem. 2023, 19, 1408–1442, doi:10.3762/bjoc.19.102

• NEt3·3HF, AgHF2 could also be used. The complexes were found to be air-stable in the solid state and moderately stable in solution. They were unambiguously characterized on the basis of NMR studies including 19F NMR and X-ray crystal analysis. With the IMes ligand, an air-stable bis(NHC)Cu(I) complex

Synthesis, structural characterization, and optical properties of benzo[f]naphtho[2,3-b]phosphoindoles

• Mio Matsumura,
• Takahiro Teramoto,
• Masato Kawakubo,
• Masatoshi Kawahata,
• Yuki Murata,
• Kentaro Yamaguchi,
• Masanobu Uchiyama and
• Shuji Yasuike

Beilstein J. Org. Chem. 2021, 17, 671–677, doi:10.3762/bjoc.17.56

• of the phosphorus atom. X-ray crystal analysis showed that the parent trivalent phosphole has a considerably planar benzonaphthophosphoindole skeleton in its crystal structure. 1H and 13C NMR observations revealed that all the phospholes obtained in this study had a highly symmetric structure in

Formation of an unexpected 3,3-diphenyl-3H-indazole through a facile intramolecular [2 + 3] cycloaddition of the diazo intermediate

• Andrew T. King,
• Hugh G. Hiscocks,
• Lidia Matesic,
• Mohan Bhadbhade,
• Roger Bishop and
• Alison T. Ung

Beilstein J. Org. Chem. 2019, 15, 1347–1354, doi:10.3762/bjoc.15.134

• the indazole ring. The ambiguity was overcome through the X-ray structural analysis of the compound. The single crystals were easily obtained by recrystallisation from CH2Cl2. Crystal structure analysis The X-ray crystal analysis revealed that the product was not the diazonium intermediate 7, but

An anomalous addition of chlorosulfonyl isocyanate to a carbonyl group: the synthesis of ((3aS,7aR,E)-2-ethyl-3-oxo-2,3,3a,4,7,7a-hexahydro-1H-isoindol-1-ylidene)sulfamoyl chloride

• Aytekin Köse,
• Aslı Ünal,
• Ertan Şahin,
• Uğur Bozkaya and
• Yunus Kara

Beilstein J. Org. Chem. 2019, 15, 931–936, doi:10.3762/bjoc.15.89

• exact configuration was determined by X-ray crystal analysis. We explain the mechanism of product formation supported by theoretical calculations. Keywords: addition reaction; chlorosulfonyl isocyanate; sulfamoyl chloride; theoretical calculations; Introduction Since its identification in 1959 [1

• spectral data. We determined the exact structure of 10 by X-ray crystal analysis (Figure 2) [18]. In addition to determining its structure, we performed X-ray crystal analysis of molecule 10 to identify the possible interactions. The structure has a racemic form, with the atoms of racemate 10 labeled and

Synthesis and photophysical properties of novel benzophospholo[3,2-b]indole derivatives

• Mio Matsumura,
• Mizuki Yamada,
• Atsuya Muranaka,
• Misae Kanai,
• Naoki Kakusawa,
• Daisuke Hashizume,
• Masanobu Uchiyama and
• Shuji Yasuike

Beilstein J. Org. Chem. 2017, 13, 2304–2309, doi:10.3762/bjoc.13.226

• -ray crystal analysis of benzophospholo[3,2-b]indoles showed that the nitrogen atoms are sp2 hybridized and the phosphorus atoms adopt pyramidal and tetrahedral geometry. A significant characteristic of the benzophosphole-fused indole derivatives is that the corresponding phosphine oxide, the

• may be associated with the low fluorescence quantum yields. Conclusion A series of novel indole-fused phospholes were synthesized by simple chemical modifications at the trivalent phosphorus center. These organophosphorus compounds generated a whole series of derivatives from only one precursor. The X

Determination of the absolute stereostructure of a cyclic azobenzene from the crystal structure of the precursor containing a heavy element

• Reji Thomas and
• Nobuyuki Tamaoki

Beilstein J. Org. Chem. 2016, 12, 2211–2215, doi:10.3762/bjoc.12.212

• ; cyclic compound; enantiomer; stereostructure; X-ray crystal analysis; Introduction Chirality is a topic of fundamental importance in several branches of science [1][2][3][4][5]. Homochirality in nature was one of the most important challenges for researchers and the origin is still unsolved [6][7][8

Synthesis of axially chiral gold complexes and their applications in asymmetric catalyses

• Yin-wei Sun,
• Qin Xu and
• Min Shi

Beilstein J. Org. Chem. 2013, 9, 2224–2232, doi:10.3762/bjoc.9.261

• residue was purified by a silica gel flash column chromatography to afford gold-complexes (S)-15a (84 mg) in 46% yield and (S)-15b (68 mg) in 37% yield. A single crystal grown from complex (S)-15a or (S)-15b in a saturated solution of CH2Cl2/pentane was suitable for X-ray crystal analysis. (S)-15a: white

• removed under reduced pressure and the residue was purified by silica gel flash column chromatography to afford gold-complex (S)-18 (603 mg) in 88% yield. A single crystal grown from complex (S)-18 in a saturated solution of CH2Cl2/pentane was suitable for X-ray crystal analysis. (S)-18: white solid; [α

• , 743, 692 cm−1; HRMS–ESI: [M + NH4]+: calcd for C32H27AuClNOP, 704.1179; found, 704.1170. Gold complex (S)-22 has been prepared by the same reaction procedure as gold complex (S)-18 in 91% yield. A single crystal grown from complex (S)-22 in a saturated solution of CH2Cl2/pentane was suitable for X-ray

Isolation and X-ray characterization of palladium–N complexes in the guanylation of aromatic amines. Mechanistic implications

• Abdessamad Grirrane,
• Hermenegildo Garcia and
• Eleuterio Álvarez

Beilstein J. Org. Chem. 2013, 9, 1455–1462, doi:10.3762/bjoc.9.165

• also Supporting Information File 1, Table S4 and Figure S20 and for full details of crystallographic data see Supporting Information File 2). Beside X-ray crystal analysis of guanidine 5a, guanidines 5a–c were also characterized by 1H, 13C and 19F NMR spectroscopy and combustion analysis (see Figures

Titanium-mediated reductive cross-coupling reactions of imines with terminal alkynes: An efficient route for the synthesis of stereodefined allylic amines

• Kebin Mao,
• Guoqin Fan,
• Yuanhong Liu,
• Shi Li,
• Xu You and
• Dan Liu

Beilstein J. Org. Chem. 2013, 9, 621–627, doi:10.3762/bjoc.9.69

• with imine 2a, the corresponding allylic amines 5b–c were obtained in 69–88% yields (Table 1, entries 2 and 3). The (E)-configuration of allylic amines 5 was confirmed by X-ray crystal analysis of 5c as shown in Figure 1 [43]. Terminal alkynes with chloro- or phenyl-functionalized alkyl chains were

• confirmed unambiguously by X-ray crystal analysis of its amide derivative 8 ((E)-N-(3-(4-bromophenyl)-1-cyclopropylallyl)-3,5-dinitro-N-phenylbenzamide) as shown in Figure 2 [43]. Careful analysis of the crude reaction mixture before silica-gel purification revealed that the normal coupling product 5q was

Synthesis of a novel chemotype via sequential metal-catalyzed cycloisomerizations

• Bo Leng,
• Stephanie Chichetti,
• Shun Su,
• Aaron B. Beeler and
• John A. Porco Jr.

Beilstein J. Org. Chem. 2012, 8, 1338–1343, doi:10.3762/bjoc.8.153

• cycloisomerization was carried out in the presence of Cu(MeCN)4PF6 followed by the addition of PtCl2 to the reaction mixture (Scheme 2b). Optimization of the one-pot conditions afforded exclusively 6 in good yield (89%). X-ray crystal analysis confirmed the structure and relative stereochemistry of polycyclic